Male development of chromosomally female mice transgenic for Sry

Nature. 1991 May 9;351(6322):117-21. doi: 10.1038/351117a0.


The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

MeSH terms

  • Animals
  • DNA
  • Female
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Mice, Transgenic
  • Morphogenesis / genetics
  • Phenotype
  • Regulatory Sequences, Nucleic Acid
  • Restriction Mapping
  • Sex Determination Analysis*
  • Species Specificity
  • Testis / embryology
  • X Chromosome
  • Y Chromosome*


  • DNA