Progressively worsening hypertrophic cardiomyopathy in a child with newly diagnosed Costello syndrome while receiving growth hormone therapy

Cardiol Young. 2010 Aug;20(4):459-61. doi: 10.1017/S1047951110000260. Epub 2010 Mar 22.

Abstract

We describe a 6-year-old boy with newly diagnosed Costello syndrome after the diagnosis of severe hypertrophic cardiomyopathy. His neonatal asymmetric septal cardiomyopathy resolved by 9 months of age but reappeared at 6 years of age. This report highlights two important concepts: the association of genetic syndromes with hypertrophic cardiomyopathy and the possibility of worsening severity of hypertrophic cardiomyopathy linked to growth hormone therapy.

Publication types

  • Case Reports

MeSH terms

  • Cardiomyopathy, Hypertrophic / diagnosis*
  • Cardiomyopathy, Hypertrophic / etiology*
  • Cardiomyopathy, Hypertrophic / therapy
  • Child
  • Costello Syndrome / complications*
  • Costello Syndrome / diagnosis*
  • Costello Syndrome / therapy
  • Human Growth Hormone / adverse effects*
  • Humans
  • Male

Substances

  • Human Growth Hormone