Local anaesthetic toxicity

Foot (Edinb). 2008 Dec;18(4):192-7. doi: 10.1016/j.foot.2008.05.002. Epub 2008 Jun 26.

Abstract

Background: Local anaesthesia has been used by British podiatrists since the early 1960s. The use of local anaesthesia has allowed for the advancement of scope of practice and the development of podiatric surgery. Local anaesthesia is however associated with potential risks and adverse reactions including toxicity.

Objectives: To review the current literature on the subject of local anaesthetic toxicity and to consider recent developments in the management of acute toxicity.

Conclusions: Local anaesthesia although safe has the potential to cause serious harm in the event of toxicity. Appropriate steps should be taken to minimise the risk of toxicity and should it occur measures should be applied to minimise the consequences of toxicity. Such measures may include the use of Intralipid for resuscitation.

Publication types

  • Review

MeSH terms

  • Amides / adverse effects
  • Anesthetics, Local / adverse effects*
  • Bupivacaine / adverse effects
  • Bupivacaine / analogs & derivatives
  • Cardiovascular Diseases / chemically induced
  • Central Nervous System Diseases / chemically induced
  • Humans
  • Levobupivacaine
  • Podiatry
  • Ropivacaine

Substances

  • Amides
  • Anesthetics, Local
  • Ropivacaine
  • Levobupivacaine
  • Bupivacaine