Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Apr;36(4):658-63.
doi: 10.1016/j.joen.2010.01.011.

Protective effects of follicle-stimulating hormone inhibitor on alveolar bone loss resulting from experimental periapical lesions in ovariectomized rats

Shengbo Liu  1 , Yong Cheng, Wangmin Xu, Zhuan Bian
Affiliations

Protective effects of follicle-stimulating hormone inhibitor on alveolar bone loss resulting from experimental periapical lesions in ovariectomized rats

Shengbo Liu et al. J Endod. 2010 Apr.

Abstract

Introduction: The direct effect of follicle-stimulating hormone (FSH) on bone resorption has been demonstrated recently. The aim of this study was to evaluate the effect of FSH inhibitor leuprorelin (LE) on alveolar bone loss resulting from experimental periapical lesions in ovariectomized (OVX) rats.

Methods: Twenty-seven female rats were randomly assigned into 4 groups and subjected to ovariectomy or sham surgery (1.6 mg/kg body weight LE or vehicle was injected immediately). One week after surgery, the pulp of each rat's bilateral lower first molars was exposed to the oral environment. Three weeks after pulpal exposure, all the animals were killed, and bilateral mandibles were extracted for histologic processing. Radiographic and histologic examination for periapical bone loss area, enzyme histochemical examination for tartrate-resistant acid phosphatase (TRAP), and immunohistochemical examination for FSH receptor (FSHR) were performed.

Results: LE significantly decreased the alveolar bone loss area and osteoclast occurrence compared with non-LE treatment ovariectomized rats (P < .05), and the number of FSHR-positive cells was significantly correlated with alveolar bone loss area (r = 0.796, P < .01).

Conclusions: LE has protective effects on alveolar bone loss resulting from experimental periapical lesions in OVX rats.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Neuroendocrinology of bone.
    Kim SM, Sultana F, Korkmaz F, Rojekar S, Pallapati A, Ryu V, Lizneva D, Yuen T, Rosen CJ, Zaidi M. Kim SM, et al. Pituitary. 2024 Dec;27(6):761-777. doi: 10.1007/s11102-024-01437-5. Epub 2024 Aug 3. Pituitary. 2024. PMID: 39096452 Review.
  • Independent Skeletal Actions of Pituitary Hormones.
    Kim SM, Sultana F, Korkmaz F, Lizneva D, Yuen T, Zaidi M. Kim SM, et al. Endocrinol Metab (Seoul). 2022 Oct;37(5):719-731. doi: 10.3803/EnM.2022.1573. Epub 2022 Sep 28. Endocrinol Metab (Seoul). 2022. PMID: 36168775 Free PMC article.
  • FSH Beyond Fertility.
    Lizneva D, Rahimova A, Kim SM, Atabiekov I, Javaid S, Alamoush B, Taneja C, Khan A, Sun L, Azziz R, Yuen T, Zaidi M. Lizneva D, et al. Front Endocrinol (Lausanne). 2019 Mar 19;10:136. doi: 10.3389/fendo.2019.00136. eCollection 2019. Front Endocrinol (Lausanne). 2019. PMID: 30941099 Free PMC article. Review.
  • FSH Level and Changes in Bone Mass and Body Composition in Older Women and Men.
    Wu KC, Ewing SK, Li X, Sigurðsson S, Guðnason V, Kado DM, Hue TF, Woods GN, Veldhuis-Vlug AG, Vittinghoff E, Zaidi M, Rosen CJ, Lang T, Kim TY, Schwartz AV, Schafer AL. Wu KC, et al. J Clin Endocrinol Metab. 2021 Sep 27;106(10):2876-2889. doi: 10.1210/clinem/dgab481. J Clin Endocrinol Metab. 2021. PMID: 34212197 Free PMC article.
  • Bone circuitry and interorgan skeletal crosstalk.
    Zaidi M, Kim SM, Mathew M, Korkmaz F, Sultana F, Miyashita S, Gumerova AA, Frolinger T, Moldavski O, Barak O, Pallapati A, Rojekar S, Caminis J, Ginzburg Y, Ryu V, Davies TF, Lizneva D, Rosen CJ, Yuen T. Zaidi M, et al. Elife. 2023 Jan 19;12:e83142. doi: 10.7554/eLife.83142. Elife. 2023. PMID: 36656634 Free PMC article.
See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources