A single oral intake of arginine does not affect performance during repeated Wingate anaerobic test

J Sports Med Phys Fitness. 2010 Mar;50(1):52-6.


Aim: The ergogenic effect of arginine has been demonstrated in research focusing on its intake before exercise. However, in these studies, the effect of arginine in combination with other various metabolites were assessed. The aim of this study was to determine whether a single oral intake of arginine, without any other compounds, 60 minutes prior to exercise, modifies performance and exercise metabolism during a repeated Wingate anaerobic test.

Methods: Six healthy, active, but not highly trained volunteers participated in the study. Subjects performed three 30s all-out supramaximal Wingate Anaerobic Tests (WAnTs) with 4 minute-interval rest periods between WAnTs.

Results: Arginine ingestion before exercise did not influence physical performance. Triple WAnTs resulted in a marked increase in white blood cell (WBC) count, lactate and ammonia concentrations, however there were no differences between arginine and the placebo trials.

Conclusion: Our data indicated that 2 g of arginine ingested in a single dose, neither induced nitrite/nitrate (NOx) concentrations changes, nor improved physical performance.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Anaerobic Threshold / physiology*
  • Analysis of Variance
  • Arginine / administration & dosage
  • Arginine / therapeutic use*
  • Cross-Over Studies
  • Double-Blind Method
  • Exercise Test
  • Exercise Tolerance / drug effects
  • Humans
  • Nitric Oxide
  • Oxygen Consumption / physiology*
  • Rest
  • Task Performance and Analysis
  • Time Factors


  • Nitric Oxide
  • Arginine