Observation of the selective staining of chromosomal DNA in dividing cells using a luminescent terbium(III) complex

Chem Commun (Camb). 2010 Apr 14;46(14):2391-3. doi: 10.1039/b924679g. Epub 2010 Feb 2.

Abstract

The emission intensity of a monocationic Tb or Eu(III) complex of a bis(1-azaxanthone) ligand is enhanced in the presence of serum albumin; the lanthanide complex stains dividing cells, allowing visualisation of mitotic chromosomes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coordination Complexes / chemistry*
  • DNA / chemistry*
  • Europium / chemistry
  • HeLa Cells
  • Humans
  • Ligands
  • Luminescence
  • Microscopy, Fluorescence
  • Terbium / chemistry*

Substances

  • Coordination Complexes
  • Ligands
  • Terbium
  • Europium
  • DNA