Smoking and AMH levels in women with normal reproductive history

Arch Gynecol Obstet. 2010 Aug;282(2):215-9. doi: 10.1007/s00404-010-1425-1. Epub 2010 Mar 23.


Purpose: To investigate the effect of age and smoking on the AMH levels in normal cycling healthy women with normal reproductive history.

Materials and methods: In 137 women, blood samples were taken on day 3 of a spontaneous cycle. Serum FSH, LH, E2, progesterone and AMH were measured in all blood samples. For the statistical analysis of the data, t test, Pearson's correlation and linear regression analysis were performed.

Results: Of 137 women (43%), 59 were smokers. Age was positively correlated with serum FSH and LH levels (r = 0.584, P < 0.001 and r = 0.330, P < 0.001, respectively) and negatively correlated with serum AMH levels (r = -0.882, P < 0.001). There were no significant differences in FSH, LH, E2, progesterone and AMH levels between smokers and non-smokers. Multiple stepwise linear regression analysis showed that in both smokers and non-smokers, age was the most significant determinant of AMH levels (r = -0.889, P < 0.001 and r = -0.944, P < 0.001, respectively), while smoking was not related to AMH levels.

Conclusions: Aging significantly decreases AMH levels in women with normal cycles and normal reproductive history, while smoking does not seem to have significant effects on AMH levels.

MeSH terms

  • Adult
  • Age Factors
  • Aging / blood*
  • Anti-Mullerian Hormone / blood*
  • Body Mass Index
  • Estradiol / blood
  • Female
  • Follicle Stimulating Hormone / blood
  • Humans
  • Luteinizing Hormone / blood
  • Menstrual Cycle / blood*
  • Middle Aged
  • Progesterone / blood
  • Reproductive History
  • Smoking / blood*
  • Young Adult


  • Progesterone
  • Estradiol
  • Anti-Mullerian Hormone
  • Luteinizing Hormone
  • Follicle Stimulating Hormone