Outcome of systemic lupus erythematosus. A study of 66 patients over 7 years with special reference to the predictive value of anti-DNA antibody determinations

Scand J Rheumatol. 1991;20(2):104-9. doi: 10.3109/03009749109165284.

Abstract

A cohort of 66 patients with SLE that were thoroughly studied, both clinically and serologically in 1980-81, when they had a mean disease duration of eight years, were evaluated seven years later in order to assess the long-range outcome of the disease. Five patients were lost from follow-up and 12 (20%) died during the follow-up. The estimated 10-year survival was 91%. A total of 30 patients (45%), showed no signs of nephritis at any stage, and in only eight an active nephritis was found during the follow-up. The previous antibody determinations, provided no predictive information regarding the behaviour of the renal manifestations. Arthralgia was the main clinical symptom during the follow-up. Hypertension developed in 23%. At the end of the follow-up the disease was regarded as active in 13% of the patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Antinuclear / analysis*
  • Cohort Studies
  • Female
  • Finland / epidemiology
  • Follow-Up Studies
  • Humans
  • Lupus Erythematosus, Systemic / epidemiology*
  • Lupus Erythematosus, Systemic / immunology
  • Lupus Erythematosus, Systemic / mortality
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prognosis
  • Survival Rate
  • Time Factors

Substances

  • Antibodies, Antinuclear