Circulating soluble CTLA-4 is related to inflammatory markers in the 70 year old population

Scand J Clin Lab Invest. 2010 Jul;70(4):237-43. doi: 10.3109/00365511003695608.

Abstract

Objective: Measurement of inflammatory mediators is an important tool to assess inflammation. We have, therefore, conducted a survey within the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study to evaluate the inter-relationship between soluble CTLA-4 (sCTLA-4) and other inflammatory markers.

Materials and methods: This is a population-based study, designed to quantify the circulating serum levels of sCTLA-4 and other inflammatory markers such as CRP and pro-inflammatory cytokines and chemokines by in-house ELISA, Immuno-turbidimetry and multiplex ELISA, respectively. A total of 1016 Swedish Caucasians aged 70 years old were recruited. The statistical analysis was performed by ANOVA.

Results: The levels of sCTLA-4 were directly related to the levels of pro-inflammatory cytokines such as IL-6, IL-1alpha, IL-1beta, TNF-alpha, IFN-gamma and chemokines such as IL-8. However, the levels of sCTLA-4 were inversely related to the levels of MCP-1. Also, we could not demonstrate any relation between the levels of sCTLA-4 and CRP or soluble adhesion molecules.

Conclusions: Circulating sCTLA-4 could be used as a biomarker for inflammation, potentially reflecting dysregulated T lymphocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antigens, CD / blood*
  • Biomarkers / blood
  • CTLA-4 Antigen
  • Cardiovascular Diseases / epidemiology
  • Chemokines / blood
  • Cytokines / blood
  • Female
  • Humans
  • Inflammation / blood*
  • Inflammation / epidemiology
  • Inflammation Mediators / blood*
  • Male
  • Risk Factors

Substances

  • Antigens, CD
  • Biomarkers
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Chemokines
  • Cytokines
  • Inflammation Mediators