Diffuse melanosis in metastatic malignant melanoma

J Am Acad Dermatol. 1991 Apr;24(4):625-8. doi: 10.1016/0190-9622(91)70096-k.


The skin of a patient with diffuse melanosis as a result of malignant melanoma was examined by light microscopy, immunohistochemistry, and electron microscopy. Our findings indicate that the slate-blue discoloration in this patient was due to pigment deposition in dermal macrophages and endothelial cells. Multiple attempts to identify disseminated metastatic melanoma cells were unsuccessful.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Male
  • Melanoma / complications
  • Melanoma / secondary*
  • Melanoma / ultrastructure
  • Melanosis / complications*
  • Melanosis / pathology
  • Middle Aged
  • Skin / ultrastructure
  • Skin Neoplasms / complications
  • Skin Neoplasms / secondary*
  • Skin Neoplasms / ultrastructure