High plasma immunoglobulin (Ig) A and low IgG antibody titers to oxidized low-density lipoprotein are associated with markers of glucose metabolism

J Clin Endocrinol Metab. 2010 May;95(5):2467-75. doi: 10.1210/jc.2009-1858. Epub 2010 Mar 23.


Context: Plasma oxidized low-density lipoprotein (OxLDL) is known to be associated with obesity, metabolic syndrome, and diabetes.

Objective: The objective of the study was to investigate the association between plasma IgA, IgM, and IgG titers to OxLDL, phosphocholine (PC), and streptococcal cell wall polysaccharide (CWPS) and markers of glucose metabolism, type 2 diabetes, and liver adiposity.

Setting and participants: A population-based cohort of middle-aged Finns (n = 1039) participated in the study.

Design: Plasma IgM, IgG, and IgA to copper oxidized LDL (CuOx-LDL) and malondialdehyde-modified low-density lipoprotein (MDA-LDL), PC, and CWPS were determined with chemiluminescent ELISA and liver adiposity with ultrasonography.

Results: IgA autoantibody titers to OxLDL and PC, but not CWPS, were positively associated with fasting blood glucose and plasma insulin levels and inversely with insulin sensitivity index. IgA to OxLDL was significantly higher (P = 0.013 for CuOx-LDL and P = 0.016 for MDA-LDL) and IgG to OxLDL significantly lower (P = 0.036 for CuOx-LDL and P = 0.001 for MDA-LDL) among the subjects with type 2 diabetes compared with subjects with normal or impaired glucose metabolism when adjusted for age, sex, body mass index, smoking, and alcohol consumption. Logistic regression analysis showed that high plasma IgA to OxLDL and low IgG to MDA-LDL were independent risk factors for type 2 diabetes. Plasma IgA titers to OxLDL demonstrated a significant association with liver adiposity (P = 0.012) and gamma-glutamyltransferase levels (P = 0.002).

Conclusions: Plasma IgA titers to OxLDL were positively and IgG titers negatively associated with markers of glucose metabolism. High plasma IgA and low IgG to OxLDL were independent risk factors for type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / anatomy & histology
  • Autoantibodies / blood
  • Biomarkers
  • Blood Glucose / metabolism*
  • Blood Pressure
  • Body Mass Index
  • Diabetes Mellitus, Type 2 / blood
  • Female
  • Humans
  • Immunoglobulin A / blood*
  • Immunoglobulin G / blood*
  • Insulin / blood
  • Lipoproteins, LDL / blood*
  • Liver / anatomy & histology
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / physiopathology
  • Middle Aged
  • Obesity / blood
  • Obesity / physiopathology


  • Autoantibodies
  • Biomarkers
  • Blood Glucose
  • Immunoglobulin A
  • Immunoglobulin G
  • Insulin
  • Lipoproteins, LDL
  • oxidized low density lipoprotein