Prevalence and management of non-albicans vaginal candidiasis

Sex Transm Infect. 2010 Apr;86(2):99-100. doi: 10.1136/sti.2009.040386.


Objectives: It is thought that widespread use of 'over-the-counter' azoles may increase the incidence of resistant Candida species such as Candida glabrata. Infections with species other than Candida albicans frequently do not respond to standard azole treatments. Intravaginal nystatin is an option but is no longer available in the UK. In this paper, the authors review the prevalence of non-albicans candida over the past 5 years, and assess the efficacy of amphotericin and flucytosine vaginal cream in the treatment of non-albicans VVC.

Methods: Retrospective review of all vaginal yeast isolates collected from women attending a city centre sexual-health clinic between 2004 and 2008. The women prescribed amphotericin and flucytosine vaginal cream were identified through pharmacy records, and their clinical notes reviewed for treatment outcome.

Results: Between 2004 and 2008, the number of isolates of all Candida species increased with increasing clinic workload, but the prevalence of non-albicans yeasts remained stable at between 0.87 and 1.06%. Eighteen patients were prescribed amphotericin and flucytosine vaginal cream. At follow-up, all 18 were clear of their initial yeast isolate on culture, but two had persistent symptoms and had positive cultures for C albicans.

Conclusions: There is no evidence of any increase in prevalence of non-albicans Candida species such as C glabrata. The authors have treated 18 women who had non-albicans VVC with amphotericin and flucytosine vaginal cream and achieved clearance of the non-albicans species in all of them.

MeSH terms

  • Administration, Intravaginal
  • Amphotericin B / administration & dosage
  • Antifungal Agents / administration & dosage
  • Candidiasis, Vulvovaginal / drug therapy
  • Candidiasis, Vulvovaginal / epidemiology*
  • Candidiasis, Vulvovaginal / microbiology
  • Drug Therapy, Combination
  • Female
  • Flucytosine / administration & dosage
  • Humans
  • Ointments
  • Prevalence
  • Retrospective Studies


  • Antifungal Agents
  • Ointments
  • Amphotericin B
  • Flucytosine