Nephrology visits and health care resource use before and after reporting estimated glomerular filtration rate

JAMA. 2010 Mar 24;303(12):1151-8. doi: 10.1001/jama.2010.303.


Context: Laboratory reporting of estimated glomerular filtration rate (GFR) has been widely implemented, with limited evaluation.

Objective: To examine trends in nephrologist visits and health care resource use before and after estimated GFR reporting.

Design, setting, and patients: Community-based cohort study (N = 1,135,968) with time-series analysis. Participants were identified from a laboratory registry in Alberta, Canada, and followed up from May 15, 2003, to March 14, 2007 (with estimated GFR reporting implemented October 15, 2004).

Main outcome measure: Nephrologist visits and patient management.

Results: Following estimated GFR reporting, the rate of first outpatient visits to a nephrologist for patients with chronic kidney disease (CKD; estimated GFR <60 mL/min/1.73 m(2)) increased by 17.5 (95% confidence interval [CI], 16.5-18.6) visits per 10,000 CKD patients per month, corresponding to a relative increase from baseline of 68.4% (95% CI, 65.7%-71.2%). There was no association between estimated GFR reporting and rate of first nephrologist visit among patients without CKD. Among patients with an estimated GFR of less than 30 mL/min/1.73 m(2), the rate of first nephrologist visits increased by 134.4 (95% CI, 60.0-208.7) visits per 10,000 patients per month. This increase was predominantly seen in women, patients aged 46 to 65 years as well as those aged 86 years or older, and those with hypertension, diabetes, and comorbidity. Reporting of estimated GFR was not associated with increased rates of internal medicine or general practitioner visits or increased use of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers among patients with CKD and proteinuria or the subgroup limited to patients with diabetes.

Conclusions: Reporting of estimated GFR was associated with an increase in first nephrologist visits, particularly among patients with more severe kidney dysfunction, women, middle-aged and very elderly patients, and those with comorbidities. Any effect on outcomes remains to be shown.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Alberta
  • Automation
  • Cohort Studies
  • Female
  • Glomerular Filtration Rate*
  • Health Resources / statistics & numerical data*
  • Humans
  • Kidney / physiopathology
  • Kidney Diseases / classification
  • Kidney Diseases / diagnosis*
  • Kidney Diseases / drug therapy
  • Kidney Diseases / physiopathology
  • Laboratories / statistics & numerical data
  • Male
  • Middle Aged
  • Nephrology / statistics & numerical data*
  • Referral and Consultation
  • Sex Factors