Hereditary nephrotic syndrome: a systematic approach for genetic testing and a review of associated podocyte gene mutations

Pediatr Nephrol. 2010 Sep;25(9):1621-32. doi: 10.1007/s00467-010-1495-0. Epub 2010 Mar 24.


Several genes have been implicated in genetic forms of nephrotic syndrome occurring in children. It is now known that the phenotypes associated with mutations in these genes display significant variability, rendering genetic testing and counselling a more complex task. This review will focus on the recent clinical findings associated with those genes known to be involved in isolated steroid-resistant nephrotic syndrome in children and, thereby, propose an approach for appropriate mutational screening. The recurrence of proteinuria after transplantation in patients with hereditary forms of nephrotic syndrome will also be discussed.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • DNA Mutational Analysis*
  • Disease Progression
  • Female
  • Genetic Counseling
  • Genetic Predisposition to Disease
  • Genetic Testing / methods*
  • Humans
  • Infant
  • Kidney Transplantation
  • Male
  • Nephrotic Syndrome / congenital
  • Nephrotic Syndrome / diagnosis*
  • Nephrotic Syndrome / genetics*
  • Nephrotic Syndrome / therapy
  • Pedigree
  • Phenotype
  • Podocytes / metabolism*
  • Predictive Value of Tests
  • Time Factors
  • Treatment Outcome