Ischemic neuronal damage after acute subdural hematoma in the rat: effects of pretreatment with a glutamate antagonist

J Neurosurg. 1991 Jun;74(6):944-50. doi: 10.3171/jns.1991.74.6.0944.


The ability of a competitive N-methyl-D-aspartate (NMDA) receptor antagonist (D-CPP-ene) to reduce irreversible brain damage has been examined in a rodent model of acute subdural hematoma. Acute subdural hematoma was produced by the slow injection of 400 microliters homologous blood into the subdural space overlying the parietal cortex in halothane-anesthetized rats. Brain damage was assessed histologically in sections at multiple coronal planes in animals sacrificed 4 hours after induction of the subdural hematoma. Pretreatment with D-CPP-ene (15 mg/kg) significantly reduced the volume of ischemic brain damage produced by the subdural hematoma from 62 +/- 8 cu mm (mean +/- standard error of the mean) in vehicle-treated control rats to 29 +/- 7 cu mm in drug-treated animals. These data demonstrate the anti-ischemic efficacy of NMDA antagonists in an animal model of intracranial hemorrhage in which intracranial pressure is elevated, and suggest that excitotoxic mechanisms (which are susceptible to antagonism by D-CPP-ene) may play a role in the ischemic brain damage which is observed in patients who die after acute subdural hematoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Ischemia / etiology
  • Brain Ischemia / pathology
  • Brain Ischemia / prevention & control*
  • Hematoma, Subdural / complications*
  • Hematoma, Subdural / pathology
  • Hemodynamics / drug effects
  • Male
  • Organophosphorus Compounds / blood
  • Organophosphorus Compounds / pharmacology*
  • Piperazines / blood
  • Piperazines / pharmacology*
  • Rats
  • Rats, Inbred Strains


  • Organophosphorus Compounds
  • Piperazines
  • SDZ EAA 494