Epithelial-mesenchymal transitions and hepatocarcinogenesis

J Clin Invest. 2010 Apr;120(4):1031-4. doi: 10.1172/JCI42615. Epub 2010 Mar 24.

Abstract

Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that has been associated with aggressive biology in hepatocellular carcinomas initiates a molecular cascade that results in EMT.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Carcinoma, Hepatocellular / etiology*
  • Carcinoma, Hepatocellular / pathology
  • Cell Differentiation
  • DNA Helicases / genetics
  • DNA Helicases / physiology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Epithelial Cells / pathology*
  • Humans
  • Liver Cirrhosis / complications
  • Liver Neoplasms / etiology*
  • Liver Neoplasms / pathology
  • Mesoderm / pathology*
  • Mice
  • cdc42 GTP-Binding Protein / physiology

Substances

  • DNA-Binding Proteins
  • DNA Helicases
  • CHD1L protein, human
  • cdc42 GTP-Binding Protein