Identification of major phenolic compounds from Nephelium lappaceum L. and their antioxidant activities

Molecules. 2010 Mar 9;15(3):1453-65. doi: 10.3390/molecules15031453.


Nephelium lappaceum is a tropical fruit whose peel possesses antioxidant properties. Experiments on the isolation and identification of the active constituents were conducted, and on their antioxidant activity using a lipid peroxidation inhibition assay. The methanolic extract of N. lappaceum peels exhibited strong antioxidant properties. Sephadex LH-20 chromatography was utilized in the isolation of each constituent and the antioxidant properties of each was studied. The isolated compounds were identified as ellagic acid (EA) (1), corilagin (2) and geraniin (3). These compounds accounted for 69.3% of methanolic extract, with geraniin (56.8%) as the major component, and exhibited much greater antioxidant activities than BHT in both lipid peroxidation (77-186 fold) and DPPH* (42-87 fold) assays. The results suggest that the isolated ellagitannins, as the principal components of rambutan peels, could be further utilized as both a medicine and in the food industry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry*
  • Antioxidants / pharmacology
  • Chromatography, High Pressure Liquid
  • Lipid Peroxidation / drug effects
  • Magnetic Resonance Spectroscopy
  • Phenols / chemistry*
  • Phenols / pharmacology
  • Sapindaceae / chemistry*
  • Spectrometry, Mass, Electrospray Ionization


  • Antioxidants
  • Phenols