Lessons on longevity from budding yeast

Nature. 2010 Mar 25;464(7288):513-9. doi: 10.1038/nature08981.

Abstract

The past decade has seen fundamental advances in our understanding of the ageing process and raised optimism that interventions to slow ageing may be on the horizon. Studies of budding yeast have made immense contributions to this progress. Yeast longevity factors have now been shown to modulate ageing in invertebrate and mammalian models, and studies of yeast have resulted in some of the best candidates for anti-ageing drugs currently in development. The first interventions to slow human ageing may spring from the humble yeast.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / pathology
  • Animals
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Longevity / physiology*
  • Nutritional Physiological Phenomena / physiology*
  • Protein Biosynthesis / physiology
  • Protein-Serine-Threonine Kinases / metabolism
  • Saccharomyces cerevisiae / physiology*
  • Sirtuins / metabolism
  • TOR Serine-Threonine Kinases

Substances

  • Intracellular Signaling Peptides and Proteins
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • Protein-Serine-Threonine Kinases
  • Sirtuins