Emerging strategies for the identification and targeting of cancer stem cells

Tumour Biol. 2010 Aug;31(4):243-53. doi: 10.1007/s13277-010-0023-y. Epub 2010 Mar 25.

Abstract

The hypothesis of cancer stem cells (CSCs) is receiving increasing interest and has become the subject of considerable debate among cancer researchers. Recent rapid progress in CSC research has encountered increasing difficulties and challenges. Understanding the biologic characteristic of CSCs is crucial to start with better identification and diagnosis based on CSC markers and eventually targeting to CSCs will undoubtedly result in improved prevention and treatment of many types of CSCs. We discuss here some of the approaching strategies that include establishing special methods of identifying CSCs and targeting therapies of CSCs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP Binding Cassette Transporter, Subfamily G, Member 5
  • ATP-Binding Cassette Transporters / metabolism
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Cell Lineage
  • Cell Separation
  • Humans
  • Lipoproteins / metabolism
  • Neoplasm Proteins / metabolism
  • Neoplastic Stem Cells / drug effects*
  • Neoplastic Stem Cells / metabolism
  • Neoplastic Stem Cells / pathology*

Substances

  • ABCG2 protein, human
  • ABCG5 protein, human
  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP Binding Cassette Transporter, Subfamily G, Member 5
  • ATP-Binding Cassette Transporters
  • Antineoplastic Agents
  • Lipoproteins
  • Neoplasm Proteins