Efficacy of Rhodotorula glutinis and Spirulina platensis carotenoids in immunopotentiation of mice infected with Candida albicans SC5314 and Pseudomonas aeruginosa 35

Folia Microbiol (Praha). 2010 Jan;55(1):61-7. doi: 10.1007/s12223-010-0010-0. Epub 2010 Mar 25.


Enhancement of the immune response leading to protection against bacterial and fungal infections was shown using different schedules of immunization with microbial pigments and a polysaccharide. The group of mice given carotenoids of Rhodotorula glutinis (preparation I) and polysaccharide of Spitulina platensis (IV) survived for 2 weeks after Pseudomonas aeruginosa infection. The groups of mice given carotenoids (I), polysaccharide (IV), I+IV and with the crude phycocyanin of S. platensis (III)+IV survived for 2 weeks after Candida albicans infection. All other groups recorded a maximum level of mortality reaching 2 mice per group either after immunization or post-infection. Adding the carotenoids, phycocyanin and polysaccharides to food as additives might therefore enhance the human immune response against microbial infections.

MeSH terms

  • Animals
  • Candida albicans / immunology
  • Candidiasis / immunology
  • Candidiasis / prevention & control*
  • Carotenoids / isolation & purification
  • Carotenoids / pharmacology*
  • Female
  • Immunologic Factors / administration & dosage*
  • Immunologic Factors / isolation & purification
  • Male
  • Mice
  • Pseudomonas Infections / immunology
  • Pseudomonas Infections / prevention & control*
  • Pseudomonas aeruginosa / immunology
  • Rhodotorula / chemistry*
  • Spirulina / chemistry*
  • Survival Analysis
  • Time Factors


  • Immunologic Factors
  • Carotenoids