Pediatric common variable immunodeficiency: immunologic and phenotypic associations with switched memory B cells

Pediatr Allergy Immunol. 2010 Aug;21(5):852-8. doi: 10.1111/j.1399-3038.2010.01004.x. Epub 2010 Mar 19.


Recent studies suggest that patients with common variable immunodeficiency (CVID) and low numbers of switched memory B cells have lower IgG levels and higher rates of autoimmune disease, splenomegaly, and granulomatous disease; however, no prior literature has focused exclusively on pediatric cases. We examined the relationship between switched memory B cells and clinical and immunologic manifestations of CVID in a pediatric population. Forty-five patients were evaluated. Patients were categorized as Group I (<5 switched memory B cells/ml, n = 24) or Group II (> or =5 switched memory B cells/mL, n = 21). CD3(+) T-cell counts and CD19(+) B-cell levels were lower among Group I patients. Only those in Group I had meningitis, sepsis, bronchiectasis, granulomatous lung disease, autoimmune cytopenias, or hematologic malignancies. Segregation of pediatric patients into high risk (Group I) and average risk (Group II) may assist in targeting surveillance appropriately.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD19 / immunology
  • Autoimmune Diseases / immunology
  • B-Lymphocytes / immunology*
  • Bronchiectasis / immunology
  • CD3 Complex / immunology
  • Child
  • Child, Preschool
  • Common Variable Immunodeficiency / immunology*
  • Female
  • Hematologic Neoplasms / immunology
  • Humans
  • Immunoglobulin Class Switching*
  • Immunologic Memory*
  • Leukemia / immunology
  • Lymphoma / immunology
  • Male
  • Meningitis / immunology
  • Plasma Cell Granuloma, Pulmonary / immunology
  • Sepsis / immunology
  • Splenomegaly / immunology


  • Antigens, CD19
  • CD3 Complex