Stealth nanoparticles: high density but sheddable PEG is a key for tumor targeting

J Control Release. 2010 Aug 3;145(3):178-81. doi: 10.1016/j.jconrel.2010.03.016. Epub 2010 Mar 23.


There are three major requirements for a nanoparticle to deliver its payload to the tumor. First, the particles need to be stable in the circulation without releasing the drug prematurely. Second, the nanoparticles accumulate in the tumor efficiently. Third, the drug is released locally in the tumor tissue or inside the tumor cells. A variety of approaches have been developed to fulfill these requirements. In this perspective, we will discuss them together with some examples.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Humans
  • Nanoparticles / adverse effects
  • Nanoparticles / chemistry*
  • Neoplasms / drug therapy
  • Pharmaceutical Preparations / administration & dosage*
  • Polyethylene Glycols / adverse effects
  • Polyethylene Glycols / chemistry*
  • Polyethylene Glycols / pharmacokinetics*


  • Pharmaceutical Preparations
  • Polyethylene Glycols