A cross-sectional epidemiological descriptive study with the purpose of identify the demographic characteristics, health aspects and life style, vulnerability to Sexually Transmitted Diseases/AIDS amongst long distance truck drivers were applied to 50 drivers from supply center of Campinas (fruit, vegetable, product wholesale market). The outcomes showed that almost all drivers interviewed were men, the majority were married, had kids, low study level and fewer than 40 years old. 70% reported abuse psychoactive drugs. The majority was aware of the importance of using condoms with casual partners; 94% reported relationship with casual partners and just 6% never used condoms. Although the small sample analyzed, the results suggests that must be implemented health promotion actions and illness prevention public politics, including the development of customized educational interventions with in this professional group.