Autofluorescence of normal and malignant bronchial tissue

Lasers Surg Med. 1991;11(2):99-105. doi: 10.1002/lsm.1900110203.


In vivo autofluorescence spectra were obtained in 5 patients with carcinoma in situ, 26 patients with invasive tumors, and 1 patient with severe dysplasia. Significant spectral differences were observed between pre-cancerous, cancerous, and normal bronchial tissues. This difference may afford a method to image and/or detect early lung cancer by using tissue autofluorescence alone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bronchi* / pathology
  • Carcinoma in Situ / diagnosis
  • Carcinoma, Bronchogenic / diagnosis*
  • Carcinoma, Bronchogenic / pathology
  • Fluorescence*
  • Fluorometry
  • Humans
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / pathology
  • Spectrometry, Fluorescence