Characterization of a murine gene expressed from the inactive X chromosome

Nature. 1991 May 23;351(6324):325-9. doi: 10.1038/351325a0.


In mammals, equal dosage of gene products encoded by the X chromosome in male and female cells is achieved by X inactivation. Although X-chromosome inactivation represents the most extensive example known of long range cis gene regulation, the mechanism by which thousands of genes on only one of a pair of identical chromosomes are turned off is poorly understood. We have recently identified a human gene (XIST) exclusively expressed from the inactive X chromosome. Here we report the isolation and characterization of its murine homologue (Xist) which localizes to the mouse X inactivation centre region and is the first murine gene found to be expressed from the inactive X chromosome. Nucleotide sequence analysis indicates that Xist may be associated with a protein product. The similar map positions and expression patterns for Xist in mouse and man suggest that this gene may have a role in X inactivation.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Cloning, Molecular
  • Cosmids
  • Crosses, Genetic
  • DNA / genetics
  • Female
  • Gene Expression*
  • Humans
  • Male
  • Meiosis
  • Mice
  • Molecular Sequence Data
  • Oligonucleotide Probes
  • Polymerase Chain Reaction / methods
  • Recombination, Genetic
  • Sequence Homology, Nucleic Acid
  • X Chromosome*


  • Oligonucleotide Probes
  • DNA

Associated data

  • GENBANK/X57450
  • GENBANK/X57451
  • GENBANK/X57452
  • GENBANK/X57453
  • GENBANK/X57454
  • GENBANK/X57455
  • GENBANK/X57688
  • GENBANK/X57689
  • GENBANK/X58436
  • GENBANK/X59289