Ventricular fibrillation and ventricular tachycardia triggered by late-coupled ventricular extrasystoles in a Brugada syndrome patient

Pacing Clin Electrophysiol. 2011 Jan;34(1):e1-5. doi: 10.1111/j.1540-8159.2010.02735.x.


Premature ventricular complexes (PVC) falling after the end of the T wave triggered ventricular fibrillation (VF) at night and monomorphic ventricular tachycardia (MVT) during daytime, in a recipient of implantable cardioverter defibrillator with Brugada syndrome. Treatment with bepridil (1) decreased the height of ST segment elevation in leads V1-V3, (2) completely eliminated VF, and (3) markedly decreased the incidence of PVC and MVT. Albeit rare, VF can be triggered by late-coupled PVC, due to a mechanism other than phase 2 reentry in some patients with Brugada syndrome.

Publication types

  • Case Reports

MeSH terms

  • Brugada Syndrome / diagnosis*
  • Electrocardiography / methods
  • Humans
  • Male
  • Tachycardia, Ventricular / diagnosis*
  • Tachycardia, Ventricular / etiology*
  • Ventricular Fibrillation / diagnosis*
  • Ventricular Fibrillation / etiology*
  • Ventricular Premature Complexes / complications*
  • Ventricular Premature Complexes / diagnosis*
  • Ventricular Premature Complexes / diet therapy*