Contrast-enhanced colour Doppler-targeted prostate biopsy: correlation of a subjective blood-flow rating scale with the histopathological outcome of the biopsy

BJU Int. 2010 Nov;106(9):1315-8; discussion 1318. doi: 10.1111/j.1464-410X.2010.09335.x.


Objective: To correlate a subjective blood-flow rating scale from contrast-enhanced colour Doppler (CECD) transrectal ultrasonography-targeted prostate biopsy with the histopathological outcome of the biopsy.

Patients and methods: In all, 760 men with a serum total prostate-specific antigen (PSA) level of ≥ 1.25 ng/mL and a free-to-total PSA ratio of < 18% were included. CECD-targeted biopsies with five cores were taken only in hypervascular areas of the peripheral zone using a second-generation ultrasonography contrast agent, followed by a 10-core systematic biopsy. Prostate blood flow was scored using a subjective 5-point scale in which 1 indicated 'benign', 2 'probably benign', 3 'indeterminate', 4 'probably malignant' and 5 'malignant'.

Results: Overall 37% (283 of 760) patients had prostate cancer in the biopsy. All 100 patients with a score of 5 had cancer; 153 had a score of 4, of whom 130 (85%) had cancer and 23 had benign histology (15%); 131 had a score of 3, of whom 34 (26%) had cancer and 97 (74%) had benign histology; 284 had a score of 2, of whom 17 (6%) had cancer and 267 (94%) had benign histology; 92 had a score of 1, of whom two (2%) had cancer and 90 (98%) had benign tissue. Statistical evaluation showed that the subjective blood-flow rating scale correlated strongly and significantly (r = 0.75, P < 0.01) with the histopathological outcome of the biopsy.

Conclusion: The present study shows that a subjective CECD blood-flow rating scale is a reliable tool to predict the pathological outcome of biopsy cores.

Publication types

  • Evaluation Study

MeSH terms

  • Biopsy, Needle / methods
  • Blood Flow Velocity
  • Cohort Studies
  • Contrast Media
  • Humans
  • Male
  • Middle Aged
  • Prostate / blood supply
  • Prostate / pathology*
  • Prostate / physiopathology
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / blood supply
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / physiopathology
  • Ultrasonography, Doppler, Color
  • Ultrasonography, Interventional


  • Contrast Media
  • Prostate-Specific Antigen