Act1, scene brain: astrocytes play a lead role

Immunity. 2010 Mar 26;32(3):302-4. doi: 10.1016/j.immuni.2010.03.009.

Abstract

Interleukin-17 (IL-17) is crucial for the progression of experimental autoimmune encephalomyelitis. In this issue of Immunity, Kang et al. (2010) report that neuroectoderm-derived astrocytes are the critical cellular element that responds to IL-17.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / deficiency
  • Adaptor Proteins, Signal Transducing / immunology*
  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Astrocytes / immunology*
  • Astrocytes / metabolism
  • Disease Progression
  • Encephalomyelitis, Autoimmune, Experimental / genetics
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Encephalomyelitis, Autoimmune, Experimental / metabolism
  • Encephalomyelitis, Autoimmune, Experimental / pathology
  • Interleukin-17 / immunology
  • Mice
  • Signal Transduction

Substances

  • Adaptor Proteins, Signal Transducing
  • Interleukin-17
  • Traf3ip2 protein, mouse