The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase

Cytokine. 2010 Jul;51(1):1-9. doi: 10.1016/j.cyto.2010.02.018. Epub 2010 Mar 27.

Abstract

Among the proteins encoded by human and simian immunodeficiency viruses (HIV and SIV) at least three, Vif, Vpu and Vpr, subvert cellular ubiquitin ligases to block the action of anti-viral defenses. This review focuses on Vpr and its HIV2/SIV counterparts, Vpx and Vpr, which all engage the DDB1.Cullin4 ubiquitin ligase complex through the DCAF1 adaptor protein. Here, we discuss the multiple functions that have been linked to Vpr expression and summarize the current knowledge on the role of the ubiquitin ligase complex in carrying out a subset of these activities.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Sequence
  • Carrier Proteins / metabolism*
  • Cullin Proteins / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Gene Products, vpr / chemistry
  • Gene Products, vpr / metabolism*
  • HIV-1 / metabolism*
  • HIV-1 / pathogenicity
  • HIV-1 / physiology
  • Humans
  • Molecular Sequence Data
  • Protein Serine-Threonine Kinases
  • Ubiquitin-Protein Ligases
  • Virus Replication

Substances

  • Carrier Proteins
  • Cullin Proteins
  • DDB1 protein, human
  • DNA-Binding Proteins
  • Gene Products, vpr
  • Ubiquitin-Protein Ligases
  • DCAF1 protein, human
  • Protein Serine-Threonine Kinases