HypC, the anthrone oxidase involved in aflatoxin biosynthesis

Appl Environ Microbiol. 2010 May;76(10):3374-7. doi: 10.1128/AEM.02495-09. Epub 2010 Mar 26.

Abstract

On the basis of gene disruption and enzyme activity, hypC, an open reading frame in the region between the pksA (aflC) and nor-1 (aflD) genes in the aflatoxin biosynthesis gene cluster, encodes a 17-kDa oxidase that converts norsolorinic acid anthrone to norsolorinic acid.

MeSH terms

  • Aflatoxins / biosynthesis*
  • Amino Acid Sequence
  • Anthracenes / chemistry
  • Anthracenes / metabolism
  • Aspergillus / enzymology*
  • Aspergillus / genetics*
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Escherichia coli / genetics
  • Fungi / enzymology
  • Fungi / genetics
  • Molecular Sequence Data
  • Multigene Family / genetics
  • Oxidoreductases / chemistry
  • Oxidoreductases / genetics*
  • Oxidoreductases / metabolism*
  • Sequence Alignment

Substances

  • Aflatoxins
  • Anthracenes
  • Bacterial Proteins
  • HypC protein, Bacteria
  • Oxidoreductases
  • anthrone