Asymmetric rostro-caudal inhibition in the primary olfactory cortex

Nat Neurosci. 2010 May;13(5):533-5. doi: 10.1038/nn.2524. Epub 2010 Mar 28.

Abstract

The importance of intracortical inhibitory circuits in setting the feature-selective spatial organization of primary sensory cortices remains controversial. To address this issue, we examined the strength of interneuron-to-pyramidal cell connections across the rat anterior piriform cortex (aPC) and found a pronounced gradient of increasing pyramidal cell inhibition along the aPC rostro-caudal axis. This functional heterogeneity could govern aPC spatial activation in response to varying odor identities and features.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anesthetics, Local / pharmacology
  • Animals
  • Animals, Newborn
  • Bicuculline / analogs & derivatives
  • Bicuculline / pharmacology
  • Electric Stimulation / methods
  • GABA Antagonists / pharmacology
  • In Vitro Techniques
  • Inhibitory Postsynaptic Potentials / drug effects
  • Inhibitory Postsynaptic Potentials / physiology
  • Lidocaine / analogs & derivatives
  • Lidocaine / pharmacology
  • Nerve Net / drug effects
  • Nerve Net / physiology*
  • Neural Inhibition / drug effects
  • Neural Inhibition / physiology*
  • Olfactory Pathways / cytology*
  • Patch-Clamp Techniques / methods
  • Photolysis
  • Pyramidal Cells / drug effects
  • Pyramidal Cells / physiology*
  • Rats
  • Terphenyl Compounds
  • gamma-Aminobutyric Acid / pharmacology

Substances

  • Anesthetics, Local
  • GABA Antagonists
  • Terphenyl Compounds
  • vialinin A
  • QX-314
  • bicuculline methiodide
  • gamma-Aminobutyric Acid
  • Lidocaine
  • Bicuculline