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Review
. 2010 Apr;11(4):573-85.
doi: 10.2217/pgs.10.37.

Use of Transcriptomics in Understanding Mechanisms of Drug-Induced Toxicity

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Free PMC article
Review

Use of Transcriptomics in Understanding Mechanisms of Drug-Induced Toxicity

Yuxia Cui et al. Pharmacogenomics. .
Free PMC article

Abstract

Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. Understanding the underlying mechanisms is critical for clinical diagnosis and management of different ADRs. Toxicogenomics can reveal impacts on biological pathways and processes that had not previously been considered to be involved in a drug response. Mechanistic hypotheses can be generated that can then be experimentally tested using the full arsenal of pharmacology, toxicology, molecular biology and genetics. Recent transcriptomic studies on drug-induced toxicity, which have provided valuable mechanistic insights into various ADRs, have been reviewed with a focus on nephrotoxicity and hepatotoxicity. Related issues have been discussed, including extrapolation of mechanistic findings from experimental model systems to humans using blood as a surrogate tissue for organ damage and comparative systems biology approaches.

Figures

Figure 1
Figure 1. Complete toxicogenomic study
Factors that need to be considered in each stage of the study are listed in the right column.

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