Abstract
We characterized 670 Clostridium difficile isolates collected from patients in 84 hospitals in Germany in 2008. PCR ribotyping showed high prevalence of ribotype 001 and restricted dissemination of ribotype 027 strains. Fluoroquinolone resistance and associated gyrase mutations were frequent in various ribotypes, but no resistance to metronidazole or vancomycin was noted.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Clostridioides difficile / drug effects*
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Clostridioides difficile / genetics
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Drug Resistance, Bacterial / genetics
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Enterocolitis, Pseudomembranous / drug therapy*
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Enterocolitis, Pseudomembranous / microbiology
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Fluoroquinolones / pharmacology
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Fluoroquinolones / therapeutic use*
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Germany / epidemiology
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Humans
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Metronidazole / pharmacology
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Microbial Sensitivity Tests
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Polymerase Chain Reaction
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Prevalence
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Ribotyping
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Vancomycin / pharmacology
Substances
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Anti-Bacterial Agents
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Fluoroquinolones
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Metronidazole
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Vancomycin