Pancreatic-portal vein fistula with disseminated fat necrosis treated by pancreaticoduodenectomy

South Med J. 1991 May;84(5):632-5.


I have reported the case of a 62-year-old man with chronic alcoholic pancreatitis and a rare pseudocyst-portal vein fistula. Even though he experienced no abdominal symptoms, he had severe metastatic fat necrosis manifested as subcutaneous fat necrosis, polyarthritis, medullary bone necrosis, and mental status changes. Remote tissue destruction continued until relief was gained by pancreaticoduodenectomy and repair of the necrotic portal vein. Disseminated fat necrosis is a rare syndrome that can be the only presenting feature in patients with pancreatitis and pancreatic cancer. Early recognition and treatment of the underlying pancreatic disease may decrease the high morality rate associated with this syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Fat Necrosis / etiology*
  • Fat Necrosis / physiopathology
  • Fat Necrosis / surgery
  • Fistula / complications*
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Fistula / complications*
  • Pancreatic Fistula / physiopathology
  • Pancreatic Fistula / surgery
  • Pancreatitis / complications*
  • Pancreatitis / surgery
  • Portal Vein*
  • Postoperative Period
  • Vascular Diseases / complications