Variable transcription factor binding: a mechanism of evolutionary change

PLoS Biol. 2010 Mar 23;8(3):e1000342. doi: 10.1371/journal.pbio.1000342.


This primer discusses a study from Bradley et al. in which changes in transcription factor binding between two Drosophila species are revealed by chromatin immunoprecipitation and high-throughput sequencing.

MeSH terms

  • Animals
  • Binding Sites
  • Biological Evolution*
  • DNA* / genetics
  • DNA* / metabolism
  • Gene Expression Regulation
  • Genome
  • Protein Binding
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*


  • Transcription Factors
  • DNA