Structure and Receptor binding properties of a pandemic H1N1 virus hemagglutinin

PLoS Curr. 2010 Mar 22;2:RRN1152. doi: 10.1371/currents.RRN1152.


The 3D-structure of the major surface viral antigen from the recent H1N1 pandemic influenza virus (A/Darwin/2001/2009) was determined to 2.8 Å resolution. The structure was used to analyze changes in the HA that have emerged during the first 11 months of the pandemic and have raised public health concerns. Receptor binding properties of this protein reveals a strict preference for human-type receptors.