Intracranial manifestations in SAPHO syndrome: the first case report in literature

Rheumatol Int. 2012 Jun;32(6):1797-9. doi: 10.1007/s00296-010-1464-8. Epub 2010 Mar 30.


A 41-year-old woman with SAPHO syndrome presented with numbness of her left arm followed by a generalized seizure. Computed tomography and magnetic resonance imaging of the brain revealed a small ring enhancing lesion in the right parietal lobe with adjacent meningeal thickening and enhancement. Surgical removal and histopathology showed evidence of severe chronic sterile inflammation and no malignant cell. Symptoms recurred and a lesion were again detected on radiological follow-up, but improvement occurred following treatment with antibiotics and biphosphonate, achieving a low inflammatory activity, reduction in CNS lesions and relative clinical well-being. This is a first report in literature about the central nervous system involvement in a patient with SAPHO syndrome.

Publication types

  • Case Reports

MeSH terms

  • Acquired Hyperostosis Syndrome / complications*
  • Acquired Hyperostosis Syndrome / diagnosis
  • Acquired Hyperostosis Syndrome / drug therapy
  • Acquired Hyperostosis Syndrome / surgery
  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Craniotomy
  • Diphosphonates / therapeutic use
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Meninges / diagnostic imaging
  • Meninges / pathology
  • Parietal Lobe / diagnostic imaging
  • Parietal Lobe / pathology
  • Recurrence
  • Seizures / diagnosis
  • Seizures / drug therapy
  • Seizures / etiology*
  • Seizures / surgery
  • Tomography, X-Ray Computed
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Diphosphonates