Adrenal function in asthmatic children treated with inhaled budesonide

Acta Paediatr Scand. 1991 Feb;80(2):213-7. doi: 10.1111/j.1651-2227.1991.tb11836.x.


The effect of the inhaled topical steroid budesonide on adrenal function was evaluated in 33 children (aged 7-15 years) with moderate bronchial asthma. The trial was designed as a prospective single-blind study of the effect of budesonide in daily doses of 200 microgram through 400 microgram to 800 micrograms in three randomized consecutive periods of 8 weeks. The unstimulated diurnal production of cortisol was assessed by measurement of free cortisol in 24-hour urine samples at the end of each period. No significant dose-related suppression was found. The cortisol production did not differ significantly during treatment with 800 microgram budesonide as compared to treatment with 200 microgram budesonide (95% confidence interval: 74%-112%). It is concluded, that budesonide is a topical steroid with a favourable ratio between topical and systemic effects in asthmatic children.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Inhalation
  • Adolescent
  • Adrenal Glands / drug effects*
  • Analysis of Variance
  • Asthma / drug therapy*
  • Bronchodilator Agents / administration & dosage
  • Bronchodilator Agents / pharmacology*
  • Budesonide
  • Child
  • Circadian Rhythm
  • Creatinine / urine
  • Dose-Response Relationship, Drug
  • Female
  • Forced Expiratory Volume / drug effects
  • Humans
  • Hydrocortisone / urine
  • Male
  • Pregnenediones / administration & dosage
  • Pregnenediones / pharmacology*
  • Prospective Studies
  • Single-Blind Method


  • Bronchodilator Agents
  • Pregnenediones
  • Budesonide
  • Creatinine
  • Hydrocortisone