Effect of pretransplant hemoglobin blood level on kidney transplant outcome

Exp Clin Transplant. 2009 Dec;7(4):214-7.

Abstract

Objectives: We investigated the effect of pretransplant hemoglobin level on the outcome of kidney transplant.

Patients and methods: Patients were divided in 2 groups: group A < 10 g/dL (80 patients; PTHb < 10 g/dL), and group B > 10 g/dL (69 patients; PTHb = 10 g/dL), and were matched regarding donor age, recipient sex, blood group, donor recipient HLA, and Cytomegalovirus status.

Results: The frequency of acute rejection, together with the timing of rejection, the need for antithymocyte globulin Fresenius rescue therapy, infection rate, and posttransplant surgical complications were comparable between both groups. While the 1-year actuarial patient and graft survival rates, delayed graft function, and slow graft function rates were comparable between both groups, longer hospital stay was required for group B (> 10 g/dL) patients (P = .005). Mean serum creatinine levels upon discharge (P = .02), at 6 months (P = .05), and 1 year (P = .02) after discharge were higher in group B (> 10 g/dL) patients. While posttransplant hemoglobin levels were lower than pretransplant levels, they were higher in group B (> 10 g/dL) compared with group A (< 10 g/dL), (P = .019).

Conclusions: Pretransplant hemoglobin level does not affect the outcome of kidney transplant, except for creatinine levels at 1 year.

Publication types

  • Retracted Publication

MeSH terms

  • Acute Disease
  • Adult
  • Anemia / blood
  • Anemia / complications*
  • Anemia / therapy
  • Biomarkers / blood
  • Communicable Diseases / blood
  • Communicable Diseases / etiology
  • Creatinine / blood
  • Delayed Graft Function / blood
  • Delayed Graft Function / etiology
  • Drug Therapy, Combination
  • Erythrocyte Transfusion
  • Female
  • Graft Rejection / blood
  • Graft Rejection / etiology
  • Graft Survival
  • Hematinics / therapeutic use
  • Hemoglobins / metabolism*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney Transplantation* / adverse effects
  • Kidney Transplantation* / mortality
  • Length of Stay
  • Male
  • Middle Aged
  • Preoperative Care
  • Time Factors
  • Treatment Outcome

Substances

  • Biomarkers
  • Hematinics
  • Hemoglobins
  • Immunosuppressive Agents
  • Creatinine