Radiotherapy: Neurocognitive considerations in the treatment of brain metastases

Nat Rev Clin Oncol. 2010 Apr;7(4):185-6. doi: 10.1038/nrclinonc.2010.30.


The results of a randomized, controlled trial investigating the neurocognitive effects of stereotactic radiosurgery (SRS), with or without whole-brain radiation therapy (WBRT), to treat brain metastases demonstrated a significant reduction in learning and memory, associated with the addition of WBRT to SRS. the results indicate that SRS monotherapy is an effective and safe initial management strategy for brain metastases.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Neoplasms / mortality
  • Brain Neoplasms / radiotherapy*
  • Brain Neoplasms / surgery
  • Cognition Disorders*
  • Disease Progression
  • Humans
  • Karnofsky Performance Status
  • Learning
  • Learning Disabilities
  • Memory
  • Memory Disorders
  • Quality of Life
  • Radiosurgery*
  • Radiotherapy*
  • Treatment Outcome