Two E-rosette-forming lymphoid cell lines

Int J Cancer. 1978 Feb 15;21(2):166-70. doi: 10.1002/ijc.2910210207.


Two E-rosette (spontaneous rosette with sheep red blood cells)-forming lymphoid cell lines were established. One (HPB-ALL) was derived from a young male Japanese patient with acute lymphoblastic leukemia (ALL), and the other (HPB-MLT) was from a 62-year-old female Japanese patient with a leukemic T-lymphoid malignancy. Formation of E rosettes, absence of any immunoglobulin determinants, absence of EBNA (Epstein-Barr virus associated nuclear antigen) and very limited stimulating ability in mixed lymphocyte culture, were characteristics mostly identical with those of so far established T-cell-derived lymphoid cell lines, MOLT, CCRF-CEM, CCRF-HS-B2, RPMI-8402 and JM. Only HPB-MLT, however, has been derived from an aged patient with T-lymphoid malignancy.

MeSH terms

  • Adolescent
  • Antigens, Viral
  • Cell Line
  • Female
  • Herpesvirus 4, Human / immunology
  • Humans
  • Leukemia / immunology*
  • Leukemia, Lymphoid / immunology*
  • Lymphocyte Culture Test, Mixed
  • Male
  • Middle Aged
  • Receptors, Antigen, B-Cell
  • Rosette Formation
  • T-Lymphocytes / immunology*


  • Antigens, Viral
  • Receptors, Antigen, B-Cell