Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

Photochem Photobiol Sci. 2010 Apr;9(4):597-600. doi: 10.1039/b9pp00130a.

Abstract

Feeding broccoli sprout extracts providing daily doses of 10 micromol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm(-2) of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brassica / chemistry*
  • Brassica / metabolism*
  • Dietary Carbohydrates / metabolism
  • Female
  • Glucosinolates / metabolism*
  • Imidoesters / metabolism*
  • Mice
  • Mice, Hairless
  • Neoplasms, Radiation-Induced / pathology
  • Neoplasms, Radiation-Induced / prevention & control*
  • Plant Extracts / pharmacology*
  • Risk
  • Skin Neoplasms / pathology
  • Skin Neoplasms / prevention & control*
  • Time Factors
  • Ultraviolet Rays / adverse effects*

Substances

  • Dietary Carbohydrates
  • Glucosinolates
  • Imidoesters
  • Plant Extracts
  • glucoraphanin