Decoding the function of nuclear long non-coding RNAs

Curr Opin Cell Biol. 2010 Jun;22(3):357-64. doi: 10.1016/ Epub 2010 Mar 29.


Long non-coding RNAs (lncRNAs) are mRNA-like, non-protein-coding RNAs that are pervasively transcribed throughout eukaryotic genomes. Rather than silently accumulating in the nucleus, many of these are now known or suspected to play important roles in nuclear architecture or in the regulation of gene expression. In this review, we highlight some recent progress in how lncRNAs regulate these important nuclear processes at the molecular level.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / genetics*
  • Chromatin Assembly and Disassembly
  • Gene Expression Regulation
  • Humans
  • RNA, Nuclear / metabolism*
  • RNA, Untranslated / metabolism*
  • Transcription, Genetic


  • RNA, Nuclear
  • RNA, Untranslated