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. 2010;17(1):25-30.
doi: 10.1258/jms.2009.009094.

Absolute numbers of lives saved and overdiagnosis in breast cancer screening, from a randomized trial and from the Breast Screening Programme in England

Stephen W Duffy  1 , Laszlo Tabar, Anne Helene Olsen, Bedrich Vitak, Prue C Allgood, Tony H H Chen, Amy M F Yen, Robert A Smith
Affiliations

Absolute numbers of lives saved and overdiagnosis in breast cancer screening, from a randomized trial and from the Breast Screening Programme in England

Stephen W Duffy et al. J Med Screen. 2010.

Erratum in

  • J Med Screen. 2010 Jun;17(2):106

Abstract

Objectives: To estimate the absolute numbers of breast cancer deaths prevented and the absolute numbers of tumours overdiagnosed in mammographic screening for breast cancer at ages 50-69 years.

Setting: The Swedish Two-County randomized trial of mammographic screening for breast cancer, and the UK Breast Screening Programme in England, ages 50-69 years.

Methods: We estimated the absolute numbers of deaths avoided and additional cases diagnosed in the study group (active study population) of the Swedish Two-County Trial, by comparison with the control group (passive study population). We estimated the same quantities for the mortality and incidence rates in England (1974-2004 and 1974-2003, respectively). We used Poisson regression for statistical inference.

Results: A substantial and significant reduction in breast cancer mortality was associated with screening in both the Two-County Trial (P < 0.001) and the screening programme in England (P < 0.001). The absolute benefits were estimated as 8.8 and 5.7 breast cancer deaths prevented per 1000 women screened for 20 years starting at age 50 from the Two-County Trial and screening programme in England, respectively. The corresponding estimated numbers of cases overdiagnosed per 1000 women screened for 20 years were, respectively, 4.3 and 2.3 per 1000.

Conclusions: The benefit of mammographic screening in terms of lives saved is greater in absolute terms than the harm in terms of overdiagnosis. Between 2 and 2.5 lives are saved for every overdiagnosed case.

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Figures

Figure 1
Figure 1
Breast cancer mortality in England 1974–2004
Figure 2
Figure 2
Breast cancer incidence in England 1974–2003
See this image and copyright information in PMC

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References

    1. Tabar L, Vitak B, Yen MFA, Chen HHT, Smith RA, Duffy SW Number needed to screen-lives saved over 20 years of follow-up in mammographic screening. J Med Screen 2004;11:126–9 - PubMed
    1. Swedish Organised Service Screening Evaluation Group Reduction in breast cancer mortality from organized service screening with mammography: 1. Further confirmation with extended data. Cancer Epidemiol Biomarkers Prev 2006;15:45–51 - PubMed
    1. Zackrisson S, Andersson I, Janzon L, Manjer J, Garne JP Rate of over-diagnosis of breast cancer 15 years after end of Malmö mammographic screening trial: follow-up study. Br Med J 2006;332:689–92 - PMC - PubMed
    1. Zahl PH, Strand BH, Maehlen J Incidence of breast cancer in Norway and Sweden during introduction of nationwide screening: prospective cohort study. BMJ 2004;328:921–4 - PMC - PubMed
    1. Duffy SW, Lynge E, Jonsson H, Ayyaz S, Olsen AH Complexities in the estimation of overdiagnosis in breast cancer screening. Br J Cancer 2008;99:1176–8 - PMC - PubMed