Implications for degenerative disorders: antioxidative activity, total phenols, flavonoids, ascorbic acid, beta-carotene and beta-tocopherol in Aloe vera

Oxid Med Cell Longev. 2009 Apr-Jun;2(2):99-106. doi: 10.4161/oxim.2.2.8493.


In order to demonstrate whether the known biological effects of Aloe vera (L.) Burm. fil. could correlate with the antioxidant activity of the plant, the antioxidant activity of the aqueous leaf extract was investigated. The present study demonstrated that the aqueous extract from A. vera leaves contained naturally occuring antioxidant components, including total phenols, flavonoids, ascorbic acid, beta-carotene and alpha-tocopherol. The extract exhibited inhibitory capacity against Fe(3+)/ascorbic acid induced phosphatidylcholine liposome oxidation, scavenged stable DPPH(*), ABTS(*+) and superoxide anion radicals, and acted as reductant. In contrast, the leaf inner gel did not show any antioxidant activity. It was concluded that the known beneficial effects of Aloe vera could be attributed to its antioxidant activity and could be related to the presence of phenolic compounds and antioxidant vitamins.

Keywords: Aloe vera; antioxidant activity; antioxidant vitamins; aqueous extract.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aloe / chemistry*
  • Antioxidants / pharmacology*
  • Ascorbic Acid / therapeutic use
  • Benzothiazoles / chemistry
  • Biphenyl Compounds / chemistry
  • Flavonoids / therapeutic use
  • Free Radical Scavengers / therapeutic use
  • Humans
  • Lipid Peroxidation / drug effects
  • Neurodegenerative Diseases / drug therapy
  • Phenols / pharmacology
  • Picrates / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Leaves / chemistry
  • Sulfonic Acids / chemistry
  • Superoxides / chemistry
  • beta Carotene / therapeutic use
  • beta-Tocopherol / therapeutic use


  • Antioxidants
  • Benzothiazoles
  • Biphenyl Compounds
  • Flavonoids
  • Free Radical Scavengers
  • Phenols
  • Picrates
  • Plant Extracts
  • Sulfonic Acids
  • beta Carotene
  • Superoxides
  • 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
  • beta-Tocopherol
  • 1,1-diphenyl-2-picrylhydrazyl
  • Ascorbic Acid