NO-Xplode: a case of supplement-associated ischemic colitis

Mil Med. 2010 Mar;175(3):202-5. doi: 10.7205/milmed-d-09-00104.


The most common cause of ischemic colitis (IC) is a sudden and transient reduction in splanchnic perfusion. In the younger population, medications are an increasingly recognized cause of ischemic bowel disease. Over-the-counter supplements may also lead to the development of ischemic colitis through similar effects. We present a case of ischemic colitis in a 42-year-old active duty service member after using the performance-enhancing supplement, NO-Xplode. In this report, we review the pharmacology of this supplement and its proposed mechanism of injury.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Adult
  • Colitis, Ischemic / chemically induced*
  • Colitis, Ischemic / diagnosis
  • Colonoscopy
  • Diagnosis, Differential
  • Dietary Supplements / adverse effects*
  • Follow-Up Studies
  • Humans
  • Male
  • Military Personnel
  • Nonprescription Drugs / administration & dosage
  • Nonprescription Drugs / adverse effects*
  • Tomography, X-Ray Computed


  • Nonprescription Drugs