Palladium-catalyzed asymmetric addition of diarylphosphines to enones toward the synthesis of chiral phosphines

Jian-Jun Feng; Xue-Feng Chen; Min Shi; Wei-Liang Duan

doi:10.1021/ja100606v

Palladium-catalyzed asymmetric addition of diarylphosphines to enones toward the synthesis of chiral phosphines

J Am Chem Soc. 2010 Apr 28;132(16):5562-3. doi: 10.1021/ja100606v.

Authors

Jian-Jun Feng¹, Xue-Feng Chen, Min Shi, Wei-Liang Duan

Affiliation

¹ School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

PMID: 20359215
DOI: 10.1021/ja100606v

Abstract

An asymmetric addition of diarylphosphines to beta-substituted enones under mild conditions using a chiral pincer-palladium catalyst has been developed for the synthesis of chiral phosphines with excellent stereoselectivity (up to 99% ee).