Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice

J Ethnopharmacol. 2010 May 27;129(2):250-3. doi: 10.1016/j.jep.2010.03.017. Epub 2010 Mar 30.


Aim of study: Extracts of Pistacia integerrima galls have been dispensed by Traditional Practitioners of Subcontinent for chest diseases as well as for aches and pains in the body. This study was planned to evaluate the possible analgesic and antiinflammatory effects of Pistacia integerrima extracts.

Materials and methods: Analgesia was determined using acetic acid induced abdominal constriction and formalin induced paw licking in mice. Antinociceptive effect was observed by thermally induced algesia in mice.

Results: Pistacia integerrima leaves extracts showed significant response against chemically induced pain (P<0.001) whereas galls extracts had highly significant protection (P<0.0001) in a dose dependent manner. In thermally induced algesia, Pistacia integerrima galls extracts 200 mg/kg (p.o.), showed significant (P<0.05) response but less than pentazocine and diclofenac, positive references. The extracts of Pistacia integerrima 50-200 mg/kg (p.o.) had modest activity against hind paw acute and chronic inflammation induced by formalin (P<0.01).

Conclusion: These results demonstrate that Pistacia integerrima extracts have antinociceptive and analgesic effects and no apparent acute toxicity on oral administration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdominal Pain / chemically induced
  • Abdominal Pain / drug therapy
  • Acetic Acid
  • Analgesics / pharmacology
  • Analgesics / therapeutic use*
  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use*
  • Diclofenac / therapeutic use
  • Dose-Response Relationship, Drug
  • Female
  • Formaldehyde
  • Hot Temperature
  • Inflammation / chemically induced
  • Inflammation / drug therapy*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Pain / chemically induced
  • Pain / drug therapy*
  • Pentazocine / therapeutic use
  • Phytotherapy*
  • Pistacia / chemistry*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Plant Leaves
  • Plant Tumors


  • Analgesics
  • Anti-Inflammatory Agents
  • Plant Extracts
  • Diclofenac
  • Formaldehyde
  • Acetic Acid
  • Pentazocine