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, 37 (5), 1016-9

Influence of STAT4 Polymorphism in Primary Sjögren's Syndrome

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Influence of STAT4 Polymorphism in Primary Sjögren's Syndrome

Rogelio J Palomino-Morales et al. J Rheumatol.

Abstract

Objective: To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren's syndrome (SS).

Methods: Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date.

Results: Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82-1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96-2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 x 10(-6), OR 1.40, 95% CI 1.21-1.62).

Conclusion: These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene.

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