Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway

Cell Signal. 2010 Sep;22(9):1282-90. doi: 10.1016/j.cellsig.2010.03.017. Epub 2010 Apr 2.


The eukaryotic transcription factor NF-kappaB regulates a wide range of host genes that control the inflammatory and immune responses, programmed cell death, cell proliferation and differentiation. The activation of NF-kappaB is tightly controlled both in the cytoplasm and in the nucleus. While the upstream cytoplasmic regulatory events for the activation of NF-kappaB are well studied, much less is known about the nuclear regulation of NF-kappaB. Emerging evidence suggests that NF-kappaB undergoes a variety of posttranslational modifications, and that these modifications play a key role in determining the duration and strength of NF-kappaB nuclear activity as well as its transcriptional output. Here we summarize the recent advances in our understanding of the posttranslational modifications of NF-kappaB, the interplay between the various modifications, and the physiological relevance of these modifications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammation / metabolism
  • Mice
  • NF-kappa B / metabolism
  • Neoplasms / metabolism
  • Protein Processing, Post-Translational*
  • Signal Transduction
  • Transcription Factor RelA / metabolism*


  • NF-kappa B
  • Transcription Factor RelA